Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
lshr_human | 545 | 5.57x57 | TM5 | C => Ter | stop gained | 8.254e-06 | 1 | 121158 | 0 | None | None | |
lshr_human | 479 | 4.38x38 | TM4 | R => Ter | stop gained | 8.241e-06 | 1 | 121340 | 0 | None | None | |
lshr_human | 342 | N-term | R => Ter | stop gained | 8.241e-06 | 1 | 121346 | 0 | None | None | ||
lshr_human | 315 | N-term | T => HisfsTer12 | frameshift | 1.626e-05 | 1 | 61514 | 0 | None | None | ||
lshr_human | 290 | N-term | Q => Ter | stop gained | 1.386e-05 | 1 | 72138 | 0 | None | None | ||
lshr_human | 288 | N-term | K => Ter | stop gained | 8.241e-06 | 1 | 121344 | 0 | None | None | ||
lshr_human | 259 | N-term | L => IlefsTer25 | frameshift | 3.296e-05 | 4 | 121364 | 0 | None | None | ||
lshr_human | 163 | N-term | T => LysfsTer8 | frameshift | 0.0004222 | 7 | 16580 | 0 | None | None | ||
lshr_human | 148 | N-term | E => Ter | stop gained | 0.0001401 | 17 | 121326 | 0 | None | None | ||
lshr_human | 110 | N-term | N => LysfsTer6 | frameshift | 8.26e-06 | 1 | 121062 | 0 | None | None | ||
lshr_human | 87 | N-term | E => Ter | stop gained | 8.259e-06 | 1 | 121078 | 0 | None | None | ||
lshr_human | 699 | C-term | C => F | missense | 8.249e-06 | 1 | 121232 | 0 | nan | 0.991 | ||
lshr_human | 699 | C-term | C => S | missense | 5.773e-05 | 7 | 121256 | 0 | nan | 0.977 | ||
lshr_human | 698 | C-term | E => Q | missense | 8.246e-06 | 1 | 121272 | 0 | nan | 0.107 | ||
lshr_human | 696 | C-term | Y => H | missense | 8.243e-06 | 1 | 121314 | 0 | nan | 0.001 | ||
lshr_human | 695 | C-term | R => H | missense | 4.121e-05 | 5 | 121334 | 0 | nan | 0.136 | ||
lshr_human | 695 | C-term | R => C | missense | 2.472e-05 | 3 | 121342 | 0 | nan | 0.0 | ||
lshr_human | 693 | C-term | K => N | missense | 8.24e-06 | 1 | 121360 | 0 | nan | 0.01 | ||
lshr_human | 692 | C-term | D => H | missense | 8.24e-06 | 1 | 121364 | 0 | nan | 0.647 | ||
lshr_human | 689 | C-term | A => D | missense | 8.239e-06 | 1 | 121374 | 0 | 0.09 | 0.075 | ||
lshr_human | 689 | C-term | A => G | missense | 2.472e-05 | 3 | 121374 | 0 | 0.18 | 0.05 | ||
lshr_human | 689 | C-term | A => T | missense | 2.472e-05 | 3 | 121374 | 0 | 0.23 | 0.002 | ||
lshr_human | 685 | C-term | C => R | missense | 8.238e-06 | 1 | 121386 | 0 | 0.22 | 0.004 | ||
lshr_human | 684 | C-term | H => N | missense | 8.238e-06 | 1 | 121384 | 0 | 0.34 | 0.001 | ||
lshr_human | 678 | C-term | L => F | missense | 8.238e-06 | 1 | 121386 | 0 | 0.15 | 0.005 | ||
lshr_human | 675 | C-term | Q => K | missense | 4.119e-05 | 5 | 121390 | 0 | 0.42 | 0.055 | ||
lshr_human | 671 | C-term | N => T | missense | 8.238e-06 | 1 | 121394 | 0 | 0.13 | 0.006 | ||
lshr_human | 671 | C-term | N => D | missense | 8.237e-06 | 1 | 121398 | 0 | 0.08 | 0.071 | ||
lshr_human | 668 | C-term | T => P | missense | 1.648e-05 | 2 | 121386 | 0 | 0.39 | 0.002 | ||
lshr_human | 667 | C-term | F => L | missense | 1.648e-05 | 2 | 121382 | 0 | 0.71 | 0.003 | ||
lshr_human | 666 | C-term | G => A | missense | 2.472e-05 | 3 | 121380 | 0 | 0.07 | 0.111 | ||
lshr_human | 662 | C-term | N => S | missense | 0.0002472 | 30 | 121362 | 0 | 0.81 | 0.009 | ||
lshr_human | 661 | C-term | S => T | missense | 8.241e-06 | 1 | 121348 | 0 | 0.07 | 0.009 | ||
lshr_human | 660 | C-term | T => S | missense | 8.241e-06 | 1 | 121344 | 0 | 0.36 | 0.027 | ||
lshr_human | 656 | C-term | F => S | missense | 8.242e-06 | 1 | 121324 | 0 | 0.62 | 0.15 | ||
lshr_human | 654 | C-term | K => N | missense | 1.649e-05 | 2 | 121274 | 0 | 0.15 | 0.005 | ||
lshr_human | 650 | C-term | L => I | missense | 8.251e-06 | 1 | 121198 | 0 | 0.46 | 0.271 | ||
lshr_human | 648 | C-term | A => D | missense | 8.253e-06 | 1 | 121166 | 0 | 0.0 | 0.955 | ||
lshr_human | 647 | C-term | R => Q | missense | 2.476e-05 | 3 | 121144 | 0 | 1.0 | 0.02 | ||
lshr_human | 647 | C-term | R => P | missense | 8.255e-06 | 1 | 121144 | 0 | 0.01 | 0.865 | ||
lshr_human | 647 | C-term | R => W | missense | 8.255e-06 | 1 | 121132 | 0 | 0.0 | 0.88 | ||
lshr_human | 646 | C-term | R => H | missense | 5.779e-05 | 7 | 121126 | 0 | 0.53 | 0.001 | ||
lshr_human | 646 | C-term | R => C | missense | 2.477e-05 | 3 | 121114 | 0 | 0.06 | 0.39 | ||
lshr_human | 644 | C-term | C => R | missense | 3.303e-05 | 4 | 121098 | 0 | 0.03 | 0.999 | PTM (Palmitoylation) | |
lshr_human | 641 | 8.61x61 | H8 | F => C | missense | 8.26e-06 | 1 | 121066 | 0 | 0.22 | 0.873 | |
lshr_human | 641 | 8.61x61 | H8 | F => L | missense | 8.26e-06 | 1 | 121060 | 0 | 0.24 | 0.011 | |
lshr_human | 639 | 8.59x59 | H8 | S => N | missense | 9.088e-05 | 11 | 121042 | 0 | 0.03 | 0.69 | |
lshr_human | 638 | 8.58x58 | H8 | L => P | missense | 1.652e-05 | 2 | 121030 | 0 | 0.0 | 0.968 | |
lshr_human | 633 | 8.53x53 | H8 | D => V | missense | 8.264e-06 | 1 | 121006 | 0 | 0.0 | 0.999 | |
lshr_human | 625 | 7.55x55 | TM7 | I => K | missense | 8.266e-06 | 1 | 120978 | 0 | 0.0 | 0.912 | GP (contact) |
lshr_human | 620 | 7.50x50 | TM7 | P => A | missense | 8.264e-06 | 1 | 121004 | 0 | 0.0 | 0.998 | SodiumPocket MicroSwitch |
lshr_human | 618 | 7.48x48 | TM7 | A => T | missense | 1.653e-05 | 2 | 121008 | 0 | 0.0 | 0.874 | |
lshr_human | 616 | 7.46x46 | TM7 | S => Y | missense | 1.653e-05 | 2 | 121020 | 0 | 0.0 | 1.0 | |
lshr_human | 614 | 7.44x43 | TM7 | I => N | missense | 8.261e-06 | 1 | 121046 | 0 | 0.0 | 0.98 | SodiumPocket MicroSwitch |
lshr_human | 614 | 7.44x43 | TM7 | I => S | missense | 8.261e-06 | 1 | 121046 | 0 | 0.0 | 0.948 | SodiumPocket MicroSwitch |
lshr_human | 613 | 7.43x42 | TM7 | P => R | missense | 8.26e-06 | 1 | 121070 | 0 | 0.0 | 1.0 | |
lshr_human | 611 | 7.41x40 | TM7 | F => V | missense | 5.78e-05 | 7 | 121102 | 0 | 0.0 | 0.999 | |
lshr_human | 607 | 7.37x36 | TM7 | L => V | missense | 4.953e-05 | 6 | 121146 | 0 | 0.0 | 0.999 | |
lshr_human | 606 | 7.36x35 | TM7 | V => A | missense | 8.255e-06 | 1 | 121144 | 0 | 0.0 | 0.547 | |
lshr_human | 602 | 7.32x31 | TM7 | T => I | missense | 8.248e-06 | 1 | 121242 | 0 | 0.0 | 1.0 | |
lshr_human | 600 | 7.30x29 | TM7 | T => I | missense | 8.246e-06 | 1 | 121266 | 0 | 0.0 | 1.0 | |
lshr_human | 599 | ECL3 | I => N | missense | 1.649e-05 | 2 | 121296 | 0 | 0.0 | 1.0 | ||
lshr_human | 596 | ECL3 | V => G | missense | 8.242e-06 | 1 | 121324 | 0 | 0.08 | 0.426 | ||
lshr_human | 590 | 6.56x56 | TM6 | I => T | missense | 1.648e-05 | 2 | 121364 | 0 | 0.0 | 0.999 | |
lshr_human | 590 | 6.56x56 | TM6 | I => V | missense | 8.239e-06 | 1 | 121370 | 0 | 0.0 | 0.998 | |
lshr_human | 585 | 6.51x51 | TM6 | I => F | missense | 8.239e-06 | 1 | 121372 | 0 | 0.0 | 1.0 | |
lshr_human | 580 | 6.46x46 | TM6 | T => I | missense | 8.237e-06 | 1 | 121400 | 0 | 0.17 | 0.911 | |
lshr_human | 578 | 6.44x44 | TM6 | D => N | missense | 2.471e-05 | 3 | 121392 | 0 | 0.02 | 0.866 | SodiumPocket MicroSwitch |
lshr_human | 575 | 6.41x41 | TM6 | I => T | missense | 8.237e-06 | 1 | 121400 | 0 | 0.0 | 0.999 | |
lshr_human | 575 | 6.41x41 | TM6 | I => V | missense | 8.237e-06 | 1 | 121402 | 0 | 0.01 | 0.998 | |
lshr_human | 560 | 6.26x26 | TM6 | A => P | missense | 8.24e-06 | 1 | 121356 | 0 | nan | 0.364 | GP (contact) |
lshr_human | 557 | ICL3 | E => K | missense | 0.001714 | 208 | 121330 | 3 | 0.12 | 0.05 | ||
lshr_human | 554 | 5.66x66 | TM5 | R => Q | missense | 4.123e-05 | 5 | 121270 | 0 | 0.34 | 0.044 | GP (contact) |
lshr_human | 543 | 5.55x55 | TM5 | C => Y | missense | 1.651e-05 | 2 | 121128 | 0 | 0.0 | 1.0 | |
lshr_human | 537 | 5.49x49 | TM5 | V => M | missense | 1.652e-05 | 2 | 121062 | 0 | 0.05 | 0.35 | |
lshr_human | 534 | 5.46x46 | TM5 | L => F | missense | 8.262e-06 | 1 | 121030 | 0 | 0.14 | 0.375 | |
lshr_human | 530 | 5.42x42 | TM5 | T => I | missense | 8.263e-06 | 1 | 121026 | 0 | 0.62 | 0.013 | |
lshr_human | 527 | 5.39x39 | TM5 | Y => C | missense | 8.262e-06 | 1 | 121036 | 0 | 0.01 | 1.0 | |
lshr_human | 522 | 5.34x34 | TM5 | T => S | missense | 8.258e-06 | 1 | 121092 | 0 | 0.13 | 0.034 | |
lshr_human | 509 | ECL2 | M => T | missense | 2.474e-05 | 3 | 121248 | 0 | 0.49 | 0.497 | ||
lshr_human | 504 | 4.63x63 | TM4 | G => S | missense | 0.0001072 | 13 | 121248 | 0 | 0.0 | 1.0 | |
lshr_human | 485 | 4.44x44 | TM4 | L => M | missense | 8.242e-06 | 1 | 121326 | 0 | 0.08 | 0.091 | |
lshr_human | 484 | 4.43x43 | TM4 | I => L | missense | 1.648e-05 | 2 | 121326 | 0 | 0.4 | 0.259 | |
lshr_human | 483 | 4.42x42 | TM4 | A => V | missense | 8.242e-06 | 1 | 121324 | 0 | 0.11 | 0.988 | |
lshr_human | 479 | 4.38x38 | TM4 | R => Q | missense | 2.473e-05 | 3 | 121332 | 0 | 0.19 | 0.379 | |
lshr_human | 476 | ICL2 | Q => K | missense | 8.241e-06 | 1 | 121344 | 0 | 0.21 | 0.213 | ||
lshr_human | 473 | ICL2 | H => Y | missense | 8.24e-06 | 1 | 121356 | 0 | 0.0 | 0.233 | ||
lshr_human | 472 | ICL2 | I => V | missense | 1.648e-05 | 2 | 121362 | 0 | 0.09 | 0.01 | ||
lshr_human | 470 | 3.56x56 | TM3 | Y => H | missense | 8.24e-06 | 1 | 121364 | 0 | 0.55 | 0.982 | GP (contact) |
lshr_human | 464 | 3.50x50 | TM3 | R => S | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
lshr_human | 461 | 3.47x47 | TM3 | T => N | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 1.0 | |
lshr_human | 460 | 3.46x46 | TM3 | I => N | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 1.0 | |
lshr_human | 459 | 3.45x45 | TM3 | V => I | missense | 1.648e-05 | 2 | 121388 | 0 | 0.03 | 0.937 | |
lshr_human | 456 | 3.42x42 | TM3 | T => S | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 0.999 | |
lshr_human | 454 | 3.40x40 | TM3 | V => I | missense | 0.0004119 | 50 | 121376 | 0 | 0.03 | 0.999 | SodiumPocket MicroSwitch |
lshr_human | 450 | 3.36x36 | TM3 | S => T | missense | 8.24e-06 | 1 | 121366 | 0 | 0.0 | 0.999 | |
lshr_human | 450 | 3.36x36 | TM3 | S => N | missense | 8.24e-06 | 1 | 121366 | 0 | 0.0 | 0.999 | |
lshr_human | 449 | 3.35x35 | TM3 | A => T | missense | 8.241e-06 | 1 | 121350 | 0 | 0.0 | 0.964 | |
lshr_human | 440 | 3.26x26 | TM3 | S => G | missense | 8.24e-06 | 1 | 121356 | 0 | 0.83 | 0.03 | |
lshr_human | 434 | ECL1 | Q => E | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 0.997 | ||
lshr_human | 431 | ECL1 | I => T | missense | 8.241e-06 | 1 | 121346 | 0 | 0.12 | 0.999 | ||
lshr_human | 428 | ECL1 | N => K | missense | 8.241e-06 | 1 | 121350 | 0 | 0.0 | 1.0 | ||
lshr_human | 428 | ECL1 | N => Y | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 1.0 | ||
lshr_human | 425 | ECL1 | Q => R | missense | 1.648e-05 | 2 | 121342 | 0 | 0.05 | 0.909 | ||
lshr_human | 421 | 2.66x66 | TM2 | Q => H | missense | 3.296e-05 | 4 | 121342 | 0 | 1.0 | 0.053 | |
lshr_human | 420 | 2.65x65 | TM2 | S => F | missense | 2.472e-05 | 3 | 121336 | 0 | 0.26 | 0.073 | |
lshr_human | 408 | 2.53x53 | TM2 | M => T | missense | 8.238e-06 | 1 | 121382 | 0 | 0.01 | 0.808 | |
lshr_human | 398 | 2.43x43 | TM2 | M => V | missense | 8.238e-06 | 1 | 121386 | 0 | 0.01 | 0.517 | |
lshr_human | 395 | 2.40x40 | TM2 | R => H | missense | 5.767e-05 | 7 | 121386 | 0 | 0.0 | 0.998 | |
lshr_human | 393 | 2.38x38 | TM2 | V => M | missense | 8.238e-06 | 1 | 121388 | 0 | 0.0 | 1.0 | |
lshr_human | 390 | ICL1 | K => R | missense | 0.0002801 | 34 | 121388 | 0 | 0.01 | 0.492 | ||
lshr_human | 389 | ICL1 | Y => C | missense | 8.238e-06 | 1 | 121392 | 0 | 0.08 | 0.182 | ||
lshr_human | 388 | ICL1 | R => H | missense | 0.0001812 | 22 | 121386 | 0 | 1.0 | 0.042 | ||
lshr_human | 388 | ICL1 | R => S | missense | 8.238e-06 | 1 | 121390 | 0 | 0.01 | 0.894 | ||
lshr_human | 386 | 1.59x59 | TM1 | T => K | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.904 | |
lshr_human | 386 | 1.59x59 | TM1 | T => R | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.965 | |
lshr_human | 380 | 1.53x53 | TM1 | V => A | missense | 3.295e-05 | 4 | 121398 | 0 | 0.01 | 1.0 | |
lshr_human | 379 | 1.52x52 | TM1 | T => A | missense | 8.237e-06 | 1 | 121398 | 0 | 0.22 | 0.588 | |
lshr_human | 364 | 1.37x37 | TM1 | V => I | missense | 8.237e-06 | 1 | 121398 | 0 | 0.31 | 0.057 | |
lshr_human | 361 | 1.34x34 | TM1 | F => S | missense | 8.237e-06 | 1 | 121402 | 0 | 0.01 | 0.998 | |
lshr_human | 357 | N-term | M => I | missense | 8.238e-06 | 1 | 121396 | 0 | 0.03 | 0.458 | ||
lshr_human | 351 | N-term | N => K | missense | 8.24e-06 | 1 | 121364 | 0 | 0.0 | 0.999 | ||
lshr_human | 351 | N-term | N => T | missense | 1.648e-05 | 2 | 121364 | 0 | 0.0 | 0.999 | ||
lshr_human | 349 | N-term | A => V | missense | 8.24e-06 | 1 | 121364 | 0 | 0.02 | 0.999 | ||
lshr_human | 347 | N-term | P => A | missense | 8.24e-06 | 1 | 121356 | 0 | 0.1 | 0.999 | ||
lshr_human | 344 | N-term | A => V | missense | 5.769e-05 | 7 | 121344 | 0 | 0.02 | 0.008 | ||
lshr_human | 342 | N-term | R => Q | missense | 2.472e-05 | 3 | 121352 | 0 | 0.61 | 0.014 | ||
lshr_human | 339 | N-term | K => R | missense | 2.473e-05 | 3 | 121328 | 0 | 0.38 | 0.02 | ||
lshr_human | 337 | N-term | L => S | missense | 0.002118 | 257 | 121326 | 3 | 0.8 | 0.002 | ||
lshr_human | 334 | N-term | G => D | missense | 2.473e-05 | 3 | 121308 | 0 | 0.89 | 0.02 | ||
lshr_human | 328 | N-term | G => R | missense | 8.248e-06 | 1 | 121242 | 0 | 0.1 | 0.541 | ||
lshr_human | 324 | N-term | S => I | missense | 8.252e-06 | 1 | 121188 | 0 | 0.18 | 0.52 | ||
lshr_human | 320 | N-term | M => T | missense | 1.653e-05 | 2 | 121018 | 0 | 0.29 | 0.027 | ||
lshr_human | 318 | N-term | S => F | missense | 8.269e-06 | 1 | 120932 | 0 | 0.03 | 0.467 | ||
lshr_human | 312 | N-term | N => S | missense | 0.6376 | 62454 | 97948 | 19594 | nan | 0.018 | ||
lshr_human | 310 | N-term | K => T | missense | 2.346e-05 | 2 | 85264 | 0 | nan | 0.646 | ||
lshr_human | 310 | N-term | K => E | missense | 1.172e-05 | 1 | 85330 | 0 | nan | 0.02 | ||
lshr_human | 298 | N-term | E => G | missense | 2.468e-05 | 2 | 81044 | 0 | 0.25 | 0.632 | ||
lshr_human | 293 | N-term | S => L | missense | 1.304e-05 | 1 | 76676 | 0 | 0.66 | 0.426 | ||
lshr_human | 291 | N-term | N => S | missense | 0.05191 | 3950 | 76090 | 97 | 0.25 | 0.998 | ||
lshr_human | 290 | N-term | Q => R | missense | 1.37e-05 | 1 | 72996 | 0 | 0.53 | 0.827 | ||
lshr_human | 289 | N-term | E => G | missense | 2.472e-05 | 3 | 121340 | 0 | 0.01 | 0.206 | ||
lshr_human | 288 | N-term | K => N | missense | 1.648e-05 | 2 | 121340 | 0 | 0.16 | 0.04 | ||
lshr_human | 287 | N-term | T => K | missense | 8.241e-06 | 1 | 121344 | 0 | 0.61 | 0.013 | ||
lshr_human | 277 | N-term | S => T | missense | 8.237e-06 | 1 | 121400 | 0 | 0.0 | 0.987 | ||
lshr_human | 267 | N-term | N => S | missense | 0.0002883 | 35 | 121394 | 0 | 1.0 | 0.1 | ||
lshr_human | 267 | N-term | N => I | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.936 | ||
lshr_human | 266 | N-term | V => L | missense | 1.648e-05 | 2 | 121394 | 0 | 0.17 | 0.145 | ||
lshr_human | 265 | N-term | F => L | missense | 8.238e-06 | 1 | 121394 | 0 | 0.44 | 0.107 | ||
lshr_human | 264 | N-term | T => I | missense | 4.119e-05 | 5 | 121390 | 0 | 0.05 | 0.633 | ||
lshr_human | 262 | N-term | R => K | missense | 8.239e-06 | 1 | 121378 | 0 | 0.06 | 0.168 | ||
lshr_human | 260 | N-term | P => S | missense | 8.239e-06 | 1 | 121370 | 0 | 0.0 | 0.995 | ||
lshr_human | 253 | N-term | S => Y | missense | 8.243e-06 | 1 | 121322 | 0 | 0.0 | 0.985 | ||
lshr_human | 249 | N-term | I => T | missense | 7.421e-05 | 9 | 121284 | 1 | 0.24 | 0.999 | ||
lshr_human | 243 | N-term | E => K | missense | 2.476e-05 | 3 | 121184 | 0 | 0.03 | 0.549 | ||
lshr_human | 242 | N-term | L => V | missense | 8.254e-06 | 1 | 121160 | 0 | 0.0 | 0.956 | ||
lshr_human | 239 | N-term | S => N | missense | 8.259e-06 | 1 | 121076 | 0 | 0.0 | 0.586 | ||
lshr_human | 236 | N-term | A => V | missense | 0.0001406 | 17 | 120928 | 0 | 0.0 | 0.902 | ||
lshr_human | 233 | N-term | K => N | missense | 8.277e-06 | 1 | 120820 | 0 | 0.03 | 0.836 | ||
lshr_human | 224 | N-term | P => L | missense | 4.118e-05 | 5 | 121410 | 0 | 0.0 | 1.0 | ||
lshr_human | 223 | N-term | G => E | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 1.0 | ||
lshr_human | 219 | N-term | R => H | missense | 6.589e-05 | 8 | 121410 | 0 | 0.05 | 0.052 | ||
lshr_human | 219 | N-term | R => C | missense | 1.647e-05 | 2 | 121410 | 0 | 0.01 | 0.901 | ||
lshr_human | 217 | N-term | A => D | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 0.908 | ||
lshr_human | 215 | N-term | N => K | missense | 8.237e-06 | 1 | 121410 | 0 | 0.34 | 0.385 | ||
lshr_human | 213 | N-term | M => I | missense | 2.471e-05 | 3 | 121410 | 0 | 1.0 | 0.009 | ||
lshr_human | 209 | N-term | H => R | missense | 8.237e-06 | 1 | 121408 | 0 | 0.28 | 0.048 | ||
lshr_human | 208 | N-term | V => I | missense | 0.001903 | 231 | 121406 | 2 | 0.21 | 0.013 | ||
lshr_human | 206 | N-term | E => Q | missense | 8.237e-06 | 1 | 121404 | 0 | 0.01 | 0.952 | ||
lshr_human | 206 | N-term | E => K | missense | 8.237e-06 | 1 | 121404 | 0 | 0.05 | 0.808 | ||
lshr_human | 205 | N-term | K => Q | missense | 1.647e-05 | 2 | 121406 | 0 | 0.0 | 1.0 | ||
lshr_human | 203 | N-term | E => D | missense | 1.647e-05 | 2 | 121406 | 0 | 0.21 | 0.03 | ||
lshr_human | 197 | N-term | T => M | missense | 3.331e-05 | 4 | 120092 | 0 | 0.0 | 0.999 | ||
lshr_human | 194 | N-term | F => V | missense | 8.311e-06 | 1 | 120320 | 0 | 0.0 | 0.992 | ||
lshr_human | 192 | N-term | H => N | missense | 8.31e-06 | 1 | 120340 | 0 | 0.01 | 0.983 | ||
lshr_human | 190 | N-term | Q => K | missense | 0.0004737 | 57 | 120324 | 1 | 0.16 | 0.285 | ||
lshr_human | 176 | N-term | S => P | missense | 3.325e-05 | 4 | 120306 | 0 | 0.17 | 0.998 | ||
lshr_human | 172 | N-term | M => I | missense | 8.288e-06 | 1 | 120658 | 0 | 0.2 | 0.688 | ||
lshr_human | 165 | N-term | P => Q | missense | 8.275e-06 | 1 | 120852 | 0 | 0.0 | 1.0 | ||
lshr_human | 164 | N-term | I => V | missense | 2.482e-05 | 3 | 120890 | 0 | 0.14 | 0.672 | ||
lshr_human | 163 | N-term | T => I | missense | 8.272e-06 | 1 | 120892 | 0 | 0.15 | 0.976 | ||
lshr_human | 163 | N-term | T => S | missense | 8.271e-06 | 1 | 120900 | 0 | 0.37 | 0.958 | ||
lshr_human | 161 | N-term | I => R | missense | 8.27e-06 | 1 | 120916 | 0 | 0.0 | 0.989 | ||
lshr_human | 157 | N-term | D => H | missense | 8.269e-06 | 1 | 120940 | 0 | 0.0 | 1.0 | ||
lshr_human | 148 | N-term | E => V | missense | 0.0001401 | 17 | 121324 | 0 | 0.1 | 1.0 | ||
lshr_human | 144 | N-term | V => I | missense | 0.0003297 | 40 | 121340 | 0 | 1.0 | 0.008 | ||
lshr_human | 144 | N-term | V => F | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 0.836 | ||
lshr_human | 137 | N-term | K => N | missense | 1.648e-05 | 2 | 121356 | 0 | 0.31 | 0.358 | ||
lshr_human | 136 | N-term | R => I | missense | 8.24e-06 | 1 | 121352 | 0 | 0.15 | 0.945 | ||
lshr_human | 132 | N-term | N => S | missense | 8.24e-06 | 1 | 121358 | 0 | 0.0 | 0.999 | ||
lshr_human | 126 | N-term | K => N | missense | 0.0006791 | 82 | 120756 | 1 | 0.0 | 0.9 | ||
lshr_human | 124 | N-term | R => Q | missense | 0.0003725 | 45 | 120810 | 0 | 0.03 | 0.962 | ||
lshr_human | 118 | N-term | A => E | missense | 8.267e-06 | 1 | 120964 | 0 | 0.0 | 0.994 | ||
lshr_human | 117 | N-term | G => A | missense | 8.266e-06 | 1 | 120982 | 0 | 0.02 | 0.981 | ||
lshr_human | 116 | N-term | P => A | missense | 8.263e-06 | 1 | 121028 | 0 | 0.13 | 0.013 | ||
lshr_human | 116 | N-term | P => S | missense | 3.305e-05 | 4 | 121028 | 0 | 0.12 | 0.153 | ||
lshr_human | 116 | N-term | P => T | missense | 1.653e-05 | 2 | 121028 | 0 | 0.06 | 0.232 | ||
lshr_human | 114 | N-term | I => V | missense | 8.26e-06 | 1 | 121060 | 0 | 0.0 | 0.855 | ||
lshr_human | 113 | N-term | Y => C | missense | 1.652e-05 | 2 | 121054 | 0 | 0.02 | 0.975 | ||
lshr_human | 113 | N-term | Y => N | missense | 0.001454 | 176 | 121062 | 1 | 0.07 | 0.094 | ||
lshr_human | 113 | N-term | Y => H | missense | 8.26e-06 | 1 | 121062 | 0 | 0.46 | 0.058 | ||
lshr_human | 112 | N-term | R => T | missense | 8.26e-06 | 1 | 121062 | 0 | 0.23 | 0.281 | ||
lshr_human | 99 | N-term | N => S | missense | 8.246e-06 | 1 | 121270 | 0 | 0.4 | 0.781 | ||
lshr_human | 97 | N-term | L => R | missense | 8.247e-06 | 1 | 121250 | 0 | 0.0 | 1.0 | ||
lshr_human | 95 | N-term | D => E | missense | 2.474e-05 | 3 | 121246 | 0 | 0.26 | 0.246 | ||
lshr_human | 92 | N-term | N => T | missense | 8.252e-06 | 1 | 121180 | 0 | 0.2 | 0.808 | ||
lshr_human | 89 | N-term | I => T | missense | 8.255e-06 | 1 | 121132 | 0 | 0.0 | 0.987 | ||
lshr_human | 86 | N-term | L => P | missense | 8.261e-06 | 1 | 121058 | 0 | 0.0 | 0.997 | ||
lshr_human | 82 | N-term | Q => R | missense | 8.272e-06 | 1 | 120892 | 0 | 0.0 | 1.0 | ||
lshr_human | 78 | N-term | I => M | missense | 8.289e-06 | 1 | 120640 | 0 | 0.0 | 1.0 | ||
lshr_human | 78 | N-term | I => V | missense | 8.267e-06 | 1 | 120958 | 0 | 0.0 | 0.998 | ||
lshr_human | 74 | N-term | E => D | missense | 8.263e-06 | 1 | 121022 | 0 | 0.41 | 0.074 | ||
lshr_human | 71 | N-term | G => R | missense | 4.13e-05 | 5 | 121060 | 0 | 0.04 | 0.998 | ||
lshr_human | 71 | N-term | G => R | missense | 8.26e-06 | 1 | 121060 | 0 | 0.04 | 0.998 | ||
lshr_human | 67 | N-term | Q => E | missense | 4.129e-05 | 5 | 121094 | 0 | 0.1 | 0.94 | ||
lshr_human | 66 | N-term | S => P | missense | 2.478e-05 | 3 | 121078 | 0 | 0.02 | 0.33 | ||
lshr_human | 65 | N-term | P => S | missense | 8.261e-06 | 1 | 121046 | 0 | 0.12 | 1.0 | ||
lshr_human | 57 | N-term | A => T | missense | 8.283e-06 | 1 | 120724 | 0 | 0.84 | 0.013 | ||
lshr_human | 48 | N-term | T => S | missense | 7.392e-05 | 1 | 13528 | 0 | 0.49 | 0.146 | ||
lshr_human | 16 | N-term | L => Q | missense | 9.203e-05 | 1 | 10866 | 0 | 0.02 | 0.0 | ||
lshr_human | 11 | N-term | L => P | missense | 9.142e-05 | 1 | 10938 | 0 | nan | 0.0 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue